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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Mutationsanalyse</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><p>Die <b>Mutationsanalyse</b> wird in der <a href="Humangenetik" title="Humangenetik">Humangenetik</a> angewandt, um <a href="Mutation" title="Mutation">Mutationen</a> ausfindig zu machen und damit festzustellen, ob ein Patient an einer <a href="Erbkrankheit" title="Erbkrankheit">Erbkrankheit</a> leidet oder nicht.
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<div class="mw-heading mw-heading2"><h2 id="Methoden_der_Mutationsanalyse">Methoden der Mutationsanalyse</h2></div>
<ul><li><a href="SSCP" title="SSCP">SSCP</a> (Single-Stranded Conformation Polymorphism Analysis)</li>
<li>DHPLC (Denaturing High Performance Liquid Chromatography, selten auch <i>Denaturating</i> <a href="Hochleistungsfl%C3%BCssigkeitschromatographie" title="Hochleistungsflüssigkeitschromatographie">HPLC</a>)</li>
<li><a href="DNA-Chip" class="mw-redirect" title="DNA-Chip">DNA-Chip</a>-Technologie</li>
<li>Two Dimensional Gene Scanning (TDSG)-Technologie</li>
<li>Conformation Sensitive Gel Electrophoresis (CSGE)-Technologie</li></ul>
<div class="mw-heading mw-heading2"><h2 id="Literatur">Literatur</h2></div>
<ul><li>B. Yu, S. A. O’Toole, R. J. Trent: <i>Somatic DNA mutation analysis in targeted therapy of solid tumours.</i> In: <i>Translational pediatrics.</i> Band 4, Nummer 2, April 2015, S. 125–138, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.3978/j.issn.2224-4336.2015.04.04">10.3978/j.issn.2224-4336.2015.04.04</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/26835368?dopt=Abstract">PMID 26835368</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729091/">PMC 4729091</a> (freier Volltext).</li>
<li>M. Gundry, J. Vijg: <i>Direct mutation analysis by high-throughput sequencing: from germline to low-abundant, somatic variants.</i> In: <i>Mutation research.</i> Band 729, Nummer 1–2, Januar 2012, S. 1–15, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.mrfmmm.2011.10.001">10.1016/j.mrfmmm.2011.10.001</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/22016070?dopt=Abstract">PMID 22016070</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237897/">PMC 3237897</a> (freier Volltext).</li></ul></div><!--htdig_noindex--><div><div class="zim-footer">
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